Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats

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Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice

BACKGROUND The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However...

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Intracranial aneurysms: flow analysis of their origin and progression.

PURPOSE To explain the origin and growth of intracranial aneurysms using the hemodynamic data obtained from a computer simulation. MATERIALS AND METHODS Pulsatile flow in an intracranial aneurysm cavity was numerically simulated based on physiologic pulsatile flow observed in the aorta. A finite element method was applied to solve the equations of motion and the non-Newtonian viscosity of blo...

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Elastic skeleton of intracranial cerebral aneurysms in rats.

In an attempt to clarify the developmental mechanism of cerebral aneurysms, we studied the elastic skeleton of experimentally induced cerebral aneurysms in rats under scanning electron microscopy after hot formic acid extraction followed by freeze-drying. We produced cerebral aneurysms in 19 rats by unilaterally ligating the common carotid artery, inducing renal hypertension, and feeding beta-a...

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endovascular treatment of intracranial aneurysms

interventional treatment of ruptured intracranial aneurysms in patients with subarachnoid hemorrhage is a standard therapy based on evidence from randomized trials. simple coiling is still used for most of the cases. modern coil technology provides a wide variety of complex shaped coils for faster procedures and reliable dense packing. the assistance of stents and balloons widens the indication...

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ژورنال

عنوان ژورنال: Journal of Neuroinflammation

سال: 2020

ISSN: 1742-2094

DOI: 10.1186/s12974-020-01802-8